88038威尼斯(中国)有限公司

【注】：列表中的同行评审期刊出版物和行业会议演示文稿包含了分析数据，这些分析数据是由筹图/HistoIndex公司Genesis®无染色数字病理学平台中获取的图像而生成的。最终解释权归本公司所有。

2024

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AI-based digital pathology provides newer insights into lifestyle intervention-induced fibrosis regression in MASLD: An exploratory study

Yuan, Hai‐Yang, et al. Liver International (2024).

Liver fibrosis showed a two-phase regression rate during long-term anti-HBV therapy by three-time biopsies assessments

Chen, S., Zhou, J., Wu, X. et al. Hepatol Int (2024). https://doi.org/10.1007/s12072-024-10643-z

Potential of Using qFibrosis Analysis to Predict Recurrent and Survival Outcome of Patients with Hepatocellular Carcinoma after Hepatic Resection
Hsiao, Chih-Yang, et al. Oncology 1-11 (2024)

Leukotriene B4 receptor 1 (BLT1) does not mediate disease progression in a mouse model of liver fibrosis

Coyne, Erin., et al. Biochem J; 481 (3): 177–190.

2023

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Digital pathology and artificial intelligence in non-alcoholic steatohepatitis: current status and future directions

Ratziu, Vlad, et al. Journal of Hepatology. October 23, 2023 DOI:https://doi.org/10.1016/j.jhep.2023.10.015

Persistent steatosis correlates with decreased fibrosis regression during anti-HBV treatment in patients with chronic HBV infection

Zhang, Mengyang and Chen, Shuyan, et al. Journal of Medical Virology 95.10 (2023): e29156.

Digital pathology for nonalcoholic steatohepatitis assessment
Arun J. Sanyal, Prakash Jha & David E. Kleiner. Nat Rev Gastroenterol Hepatol 21, 57–69 (2024).

Collagen co-localized with macrovesicular steatosis better differentiates fibrosis progression in non-alcoholic fatty liver disease mouse models    

Xiao-Xiao Wang, Rui Jin, Xiao-He Li, Qiang Yang, Xiao Teng, Fang-Fang Liu, Nan Wu, Hui-Ying Rao, Feng Liu

Understanding early stage fibrosis in NASH non-human primate model using AI digital pathology

Desiree Abdurrachim, Charlene Ong, Rahillah Binte Yusri, Ashmita Saigal, Yongqi Zhou, Muhammad Rifqi Aulia Yahya, Christopher Hendra, Samata Kakkad, Michelle Ngo, Radha Krishnan, Annaswamy Raji, Geoffrey Walford, Thomas Forest, Shubing Wang, Richard Baumgartner, Chih-Liang Chin, Saswata Talukdar, Asad Abu Bakar Ali (SHC Poster Presentation, 2023)

Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis:Results from the Phase 2b TANDEM
Quentin M Anstee, Kathryn J Lucas, Sven Francque, Manal F Abdelmalek, Arun J Sanyal, Vlad Ratziu, Adrian C Gadano, Mary Rinella, Michael Charlton, Rohit Loomba, Edward Mena, Jörn M Schattenberg, Mazen Noureddin, Donald Lazas, George BB Goh, Shiv Kumar Sarin, Yusuf Yilmaz, Miljen Martic, Rowan Stringer, Jossy Kochuparampil, Li Chen, Gerardo Rodriguez-Araujo, Elaine Chng, Nikolai V Naoumov, Clifford Brass. Hepatology (2023). doi: 10.1097/HEP.0000000000000439

Second-Harmonic Generated Quantifiable Fibrosis Parameters Provide Signatures for Disease Progression and Regression in Nonalcoholic Fatty Liver Disease
Nicole Ng, Dean Tai, Yayun Ren, Elaine Chng, Mulugeta Seneshaw, Faridoddin Mirshahi, Michael Idowu, Amon Asgharpour, and Arun J Sanyal. Clinical Pathology (2023). doi:10.1177/2632010X231162317

Tropifexor for Non-alcoholic Steatohepatitis: An Adaptive, Randomized, Placebo-controlled Phase 2a/b Trial
Arun J. Sanyal, Patricia Lopez, Eric J. Lawitz, Kathryn J. Lucas, Juergen Loeffler, Won Kim, George B.B. Goh, Jee-Fu Huang, Carla Serra, Pietro Andreone, Yi-Cheng Chen, Stanley H.Hsia, Vlad Ratziu, Diego Aizenberg, Hiroshi Tobita, Aasim M. Sheikh, John M. Vierling, Yoon Jun Kim, Hideyuki Hyogo, Dean Tai, Zachary Goodman, Felicity Schaefer, Ian R.I. Carbarns, Sophie Lamle, Miljen Martic, Nikolai V. Naoumov, Clifford A. Brass. Nature Medicine (2023). 29, 392–400. https://doi.org/10.1038/s41591-022-02200-8

Machine Learning Liver Histology Scores Correlate with Portal Hypertension Assessments in Nonalcoholic Steatohepatitis Cirrhosis
Mazen Noureddin, Zachary Goodman, Dean Tai, Elaine L. K. Chng, Yayun Ren, Pol Boudes, Harold Shlevin, Guadalupe Garcia-Tsao, Stephen A. Harrison, Naga P. Chalasani. Alimentary Pharmacology & Therapeutics (2023). https://doi.org/10.1111/apt.17363

2022

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FIBROSIS AND CANCER IN THE LIVER 

• Breakthroughs in Therapies for NASH and Remaining Challenges

 Vlad Ratziu, Sven Francque, Arun Sanyal. J Hepatol. 2022 Jun;76(6):1263-1278. doi: 10.1016/j.jhep.2022.04.002.

• Digital Pathology with Artificial Intelligence Analyses Provides Greater Insights into treatment-induced Fibrosis Regression in NASH

Naoumov NV, Brees D, Loeffler J, Chng E, Ren Y, Lopez P, Tai D, Lamle S, Sanyal AJ. Journal of Hepatology (2022), doi: https://doi.org/10.1016/j.jhep.2022.06.018. Online ahead of print.

• Developing a New qFIBS Model Assessing Histological Features in Pediatric Patients With Non-alcoholic Steatohepatitis
Feng Liu, Lai Wei, Wei Qiang Leow, Shu-Hong Liu, Ya-Yun Ren, Xiao-Xiao Wang, Xiao-He Li, Hui-Ying Rao, Rui Huang, Nan Wu, Aileen Wee and Jing-Min Zhao. Frontiers. Med., 27 June 2022. https://doi.org/10.3389/fmed.2022.925357

• Impact of resmetirom-mediated reductions in liver volume and steatosis compared with placebo on the quantification of fibrosis using second harmonic generation in a serial liver biopsy study
Presenter: Dr. Stephen Harrison. EASL ILC 2022 Oral Presentation. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Impact of artificial intelligence assistive tool on the histopathologic review of fibrosis in non-alcoholic steatohepatitis patients
Presenter: Dr. Elaine Chng. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Using qFibrosis analysis to predict disease and survival outcome of patients with hepatocellular carcinoma after surgical treatment
Presenter: Dr. Dean Tai. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Addressing the heterogeneity of fibrosis in liver biopsy specimens with qFibrosis – a new paradigm for an old problem
Presenter: Dr. David E Kleiner. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Use of second-harmonic generation microscopy for automated detection of septa and nodules in needle liver biopsies of NASH cirrhosis
Presenter: Dr. Mazen Noureddin. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Derivation of machine learning histologic scores correlating with portal pressures and the development of varices in NASH patients with cirrhosis
Presenter: Dr. Mazen Noureddin. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Magnetic Resonance Elastography (MRE) demonstrate the strongest correlation with digital pathology and NASH CRN fibrosis assessments, compared to transient elastography and other assessed non-invasive tests (NITs)
Presenter: Dr. Miljen Martic. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Second harmonic generation microscopy can quantify and subclassify early stages of NASH fibrosis progression: data from a screen-failure cohort of a NASH phase 2 study
Presenter: Prof. Dr. Quentin Anstee. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Clinical relevance of an animal model of nonalcoholic steatohepatitis (NASH) and digital pathology with artificial intelligence (DP-AI) analyses of hepatic fibrosis
Presenter: Dr. Xu Deming. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Characterisation of the novel Galectin-3 inhibitor GB1107 on CCl4-induced liver fibrosis in mice
Presenter: Dr. Alison MacKinnon. EASL ILC 2022 Poster. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform.

• Artificial Intelligence Improves Pathologist Agreement for Fibrosis Scores in Non-alcoholic Steatohepatitis Patients

Gwyneth S T Soon, Feng Liu, Wei-Qiang Leow, Aileen Wee, Lai Wei, Arun J Sanyal. Clin Gastroenterol Hepatol. 2022 Jun 10;S1542-3565(22)00555-9. doi: 10.1016/j.cgh.2022.05.027. Online ahead of print.

• Complexity of Ballooned Hepatocyte Feature Recognition: Defining a Training Atlas for Artificial Intelligence-based Imaging in NAFLD

Elizabeth M. Brunt∗, Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine Chng, Yayun Ren, George Goh Boon Bee, Elizabeth E. Powell, Mary Rinella, Arun J. Sanyal, Brent Neuschwander-Tetri, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen A. Harrison, Dean Tai∗, Quentin M. Anstee∗. Journal of Hepatology. Published January 24, 2022. https://doi.org/10.1016/j.jhep.2022.01.011. ∗ Joint senior and corresponding authors

FIBROSIS AND CANCER IN OTHER ORGANS

• Multi-photon Microscopy for the Evaluation of Interstitial Fibrosis in Extended Criteria Donor Kidneys: A Proof-of-Concept Study
Wei Zheng So, Rachel Zui Chih Teo, Li Yin Ooi, Benjamin Yen Seow Goh, Jirong Lu, Anantharaman Vathsala, Thomas Paulraj Thamboo, Ho Yee Tiong. Clinical Transplantation. 2022 May 22;e14717. doi: 10.1111/ctr.14717.

• Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery
Li-Fong Seet; Zhu Li Yap; Stephanie W. L. Chu; Li Zhen Toh; Farah Ilyana Ibrahim; Xiao Teng; Tina T. Wong. Translational Vision Science & Technology January 2022, Vol.11, 30. doi:https://doi.org/10.1167/tvst.11.1.30.

2021

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FIBROSIS AND CANCER IN THE LIVER 

• Digital Pathology with Artificial Intelligence Analyses (DP-AI) Overcomes the Limitations of Current Scoring Systems in Assessing Fibrosis Regression for NASH F3 Patients
Arun Sanyal. AASLD TLMdX 2021, Oral Presentation. Parallel 10: Diagnostics and Biomarkers of NAFLD.

• Safety and Efficacy of Tropifexor plus Cenicriviroc Combination Therapy in Adult Patients with Fibrotic NASH: 48 Week Results from the Phase 2b TANDEM Study
Quentin Anstee. AASLD TLMdX 2021, Oral Presentation. Parallel 21: NAFLD and NASH: Clinical Trials of Novel Therapeutics.

• Unique Fibrosis Progression and Regression Features in NAFLD, Validation of Concept in Animal and Human Studies Using Artificial Intelligence Analyses (DP-AI)
Dean Tai, Amon Asgharpour, Yayun Ren, Mulugeta Seneshaw, Faridoddin Mirshahi, Arun Sanyal. AASLD TLMdX 2021 ePoster.

• The Complexity of Ballooned Hepatocyte Identification: Time to Rethink Trial Endpoints for Nonalcoholic Steatohepatitis?
Elizabeth M Brunt, Andrew Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Karolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Arun Sanyal, Brent Tetri, Mary Rinella, Vincent Wong, George Goh Boon Bee, Elizabeth Powell, Lai Wei, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen Harrison, Elaine Chng, Yayung Ren, *Dean Tai, *Quentin M Anstee. AASLD TLMdX 2021 ePoster.

• Development of Machine Learning Histological Scores that Correlated with Portal Pressures and Development of Varices in NASH patients with Cirrhosis
Mazen Noureddin, Zachary D. Goodman, Dean Tai, Yayun Ren, Elaine Chng, Pol Boudes, Harold Shlevin, Stephen Harrison, Naga P. Chalasani. AASLD TLMdX 2021 ePoster (Poster of Distinction).

• qFIBS Performance in Pediatric Non-Alcoholic Steatohepatitis
Feng Liu1*, Lai Wei*, Wei Qiang Leow, Shu-Hong Liu, Xiao-Xiao Wang, Xiao-He Li, Hui-Ying Rao, Rui Huang, Nan Wu, Aileen Wee, Jing Min Zhao. AASLD TLMdX 2021 ePoster.

• Second Harmonic Generation (SHG)/Two-Photon Excitation Fluorescence (TPEF) Microscopy Imaging and Quantitative Assessment of Septa Fibrosis in Choline Deficient High Fat Diet (CDHFD) Rat Model of Nonalcoholic Steatohepatitis (NASH)
Xiao Teng, Rohan Manohar, Hiroaki Yashiro, Qiang Yang, Alvin Leong, Gideon Ho. AASLD TLMdX 2021 ePoster.

• SHG/TPEF Microscopy Imaging in the Fibrosis and Steatosis Progression of Nonalcoholic Fatty Liver Disease (NAFLD) in Mouse Models
Wang Xiaoxiao, Rui Jin, Xiao-He Li, Qiang Yang, Xiao Teng, Nan Wu, Hui-Ying Rao, Feng Liu. AASLD TLMdX 2021 ePoster.

• qVessel, a Machine Learning-based Algorithm, Accurately Stages Liver Biopsies with Chronic Liver Disease, based on Automated Vessel Counting
Zhengxin Li, Tingting Zhu, Zhao Zhi-min, Qiang Yang, Xiao Teng, Ya-yun Ren, Dean Tai, Ian Wanless, Cheng-hai Liu. AASLD TLMdX 2021 ePoster.

• Predict Early Recurrence of Resectable Hepatocellular Carcinoma Using Multi-Dimensional Artificial Intelligence Analysis of Liver Fibrosis
Liu, I.-T.; Yen, C.-S.; Wang, W.-L.; Tsai, H.-W.; Chu, C.-Y.; Chang, M.-Y.; Hou, Y.-F.; Yen, C.-J. Cancers 2021, 13, 5323. https://doi.org/10.3390/cancers13215323

• Diet and Exercise Reduce Pre-existing NASH and Fibrosis and Have Additional Beneficial Effects on the Vasculature, Adipose Tissue and Skeletal Muscle via Organ-crosstalk
Anita M. van den Hoek, Jelle C.B.C. de Jong, Nicole Worms, Anita van Nieuwkoop, Marijke Voskuilen, Aswin L. Menke, Serene Lek, Martien P.M. Caspers, Lars Verschuren, Robert Kleemann. Metabolism. 2021 Nov;124:154873. doi: 10.1016/j.metabol.2021.154873. Epub 2021 Sep 1.

• Digital Pathology with Artificial Intelligence Analyses Reveal New Dynamics of Treatment Induced Fibrosis Regression in Nonalcoholic Steatohepatitis
Nikolai V. Naoumov, Dominique Brees, Juergen Loeffler, Elaine Chng, Yayun Ren, Patricia Lopez, Dean Tai, Arun Sanyal, Sophie Lamle. PO#889. Available to registered delegates of the EASL International Liver Congress 2021. Read press release here.

• AI Digital Pathology Using qFibrosis Reveals Heterogeneity of Fibrosis Regression in Hepatitis B and Hepatitis C Patients with SVR
Feng Liu, Yameng Sun, Dean Tai, Yayun Ren, Elaine Chng, Aileen Wee, Pierre Bedossa, Rui Huang, Jian Wang, Lai Wei, Hong You, Huiying Rao. PO#1857. Available to registered delegates of the EASL International Liver Congress 2021.

• Digital Pathology to Assess Pathobiology and Treatment Response in NAFLD
Presenter: Nikolai V. Naoumov. EASL Basic Science Seminar. Artificial intelligence, “Omics” and Big Data in Liver Research - Emerging Technologies. Available to registered delegates of the EASL International Liver Congress 2021.

• Second Harmonic Generation (SHG) Microscopy and Hepatic Venous Pressure Gradient-based Validation of a Novel Histological Staging System for Alcoholic Hepatitis

Archana Rastogi, Nayana Patil, Rakhi Maiwall, Chhagan Bihari, Ananda Soshee & Shiv K. Sarin. Virchows Arch (02 April 2021). https://doi.org/10.1007/s00428-021-03089-3.

• Artificial Intelligence in Prediction of Non-alcoholic Fatty Liver Disease and Fibrosis
Grace Lai-Hung Wong, Pong-Chi Yuen, Andy Jinhua Ma, Anthony Wing-Hung Chan, Howard Ho-Wai Leung and Vincent Wai-Sun Wong. 2021 Mar;36(3):543-550. doi: 10.1111/jgh.15385. PMID: 33709607.

• Reliable Computational Quantification of Liver Fibrosis is Compromised by Inherent Staining Variation
Stuart Astbury, Jane I Grove, David A Dorward, Indra N Guha, Jonathan A Fallowfield, Timothy J Kendall. J Pathol Clin Res. 2021 Jun 2. doi: 10.1002/cjp2.227. Online ahead of print.

• Quantification of Extracellular Matrix Features and its Implications in Hepatocellular Carcinoma Patients after Curative Liver Resection
Presenting Author: Prof. Dr. Kai-Wen Huang. ePoster P095. Digital Liver Cancer Summit 2021.

• The Significance Of Quantified Extracellular Matrix Features In Patients With Hepatocellular Carcinoma After Curative Liver Resection
Presenting Author: Prof. Dr. Chih-Yang Hsiao. Poster No. 033. APASL 2021.

• Dynamic Fibrosis Features in HCV Post-treatment Liver Biopsies and Its Interpretation
Presenting Author: Prof Feng Liu. Poster No. 070. APASL 2021.

• Predict Early Recurrence of Hepatocellular Carcinoma Using Multi-dimensional Artificial Intelligence Analysis of Liver Fibrosis
Presenting Author: Prof. Dr. I-ting Liu. Poster No. 175. APASL 2021. 

• Improved Second Harmonic Generation and Two-photon Excitation Fluorescence Microscopy-based Quantitative Assessments of Liver Fibrosis through Auto-correction and Optimal Sampling
Chih-Yang Hsiao, Xiao Teng, Tung-Hung Su, Po-Huang Lee, Jia-Horng Kao, Kai-Wen Huang. Quantitative Imaging in Medicine and Surgery, North America. Submitted Mar 05, 2020. Accepted for publication Sep 11, 2020. Online Nov 11, 2020. Published in January 2021. Available at https://qims.amegroups.com/article/view/55021. doi: 10.21037/qims-20-394.

FIBROSIS AND CANCER IN OTHER ORGANS

• Bimodal Fibrosis in a Novel Mouse Model of Bleomycin-induced Usual Interstitial Pneumonia
Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa. Life Sci Alliance. 2021 Nov 2;5(1):e202101059. doi: 10.26508/lsa.202101059. Print 2022 Jan.

• Assessment of Renal Fibrosis and Anti‐fibrotic Agents using a Novel Diagnostic and Stain‐free Second‐Harmonic Generation Platform
Sadman Bhuiyan, Matthew Shen, Sharenya Chelvaretnam, Andre Y. Tan, Gideon Ho, Mohammed Akhter Hossain, Robert E. Widdop, Chrishan S. Samuel. FASEB Volume 35, Issue 5, May 2021, e21595. First published 28 April 2021. https://doi.org/10.1096/fj.202002053RRR.

2020

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FIBROSIS AND CANCER IN THE LIVER

• Safety and Efficacy of Tropifexor in Patients with Fibrotic Nonalcoholic Steatohepatitis: 48-week Results from Part C of the Phase 2 FLIGHT-FXR Study
Prof. Arun Sanyal, The Liver Meeting Digital Experience (TLMx). 13-16 November 2020. Available to registered attendees of the TLMx.Read press release here.

• Updates in the Quantitative Assessment of Liver Fibrosis for Nonalcoholic Fatty Liver Disease: Histological Perspective
Soon G, Wee A. Clin Mol Hepatol. 2020 Nov 19. doi: 10.3350/cmh.2020.0181. Epub ahead of print. PMID: 33207115.

• Improved Second Harmonic Generation and Two-photon Excitation Fluorescence Microscopy-based Quantitative Assessments of Liver Fibrosis through Auto-correction and Optimal Sampling
Chih-Yang Hsiao, Xiao Teng, Tung-Hung Su, Po-Huang Lee, Jia-Horng Kao, Kai-Wen Huang. Quantitative Imaging in Medicine and Surgery, North America. Submitted Mar 05, 2020. Accepted for publication Sep 11, 2020. Online Nov 11, 2020. Available at https://qims.amegroups.com/article/view/55021. doi: 10.21037/qims-20-394.

• Dynamic Fibrosis Features in Post-treatment Biopsies and its Interpretation

Elaine Lay Khim Chng, Dean Tai, Yayun Ren, Pierre Bedossa. Poster Presentation, Digital Paris NASH Meeting 2020. 22-23 October 2020.

• BMS-986263 (Novel Targeted Lipid Nanoparticle Delivering HSP47 siRNA) Safety and Target Engagement in Patients with Advanced Hepatic Fibrosis: Week 36 Results from a Phase 2 Randomized, Double-blind, Placebo-controlled Trial
Eric Lawitz et. al. LBP17, EASL Digital International Liver Congress 2020. Available to registered attendees of the DILC 2020.

• An Improved qFibrosis Algorithm for Precise Screening and Enrollment into Non-Alcoholic Steatohepatitis (NASH) Clinical Trials
Leow, Wei-Qiang; Bedossa, Pierre; Liu, Feng; Wei, Lai; Lim, Kiat-Hon; Wan, Wei-Keat; Ren, Yayun; Chang, Jason .-E.; Tan, Chee-Kiat; Wee, Aileen; Goh, George .-B. Diagnostics (Basel). 2020 Aug 28;10(9):E643. https://doi.org/10.3390/diagnostics10090643.

 • qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients with Non-Alcoholic Steatohepatitis
Liu F, Boon-BeeGoh G, Tiniakos D, Wee A, Leow W, Zhao JM, Rao HY, Wang X, Wang Q, Wan WK, Lim KH, Romero-Gomez M, Petta S, Bugianesi E, Tan CK, Harrison SA, Anstee QM, Chang PJ, Wei L. Hepatology 2020 Jun;71(6):1953-1966. doi: 10.1002/hep.30986. Epub 2020 May 7.

• Quantifying and Monitoring Fibrosis in Non-alcoholic Fatty Liver Disease Using Dual-photon Microscopy

Yan Wang, Grace Lai-Hung Wong, Fang-Ping He, Jian Sun, Anthony Wing-Hung Chan, Jinlian Yang, Sally She-Ting Shu, Xieer Liang, Yee Kit Tse, Xiao-Tang Fan, Jinlin Hou, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong. Gut, 2020 Jun;69(6):1116-1126. http://dx.doi.org/10.1136/gutjnl-2019-318841. Epub 28 Sep 2019.

• Long-Term Obeticholic Acid Therapy Improves Histological Endpoints in Patients With Primary Biliary Cholangitis
Christopher L. Bowlus, Paul J. Pockros, Andreas E. Kremer, Albert Parés, Lisa M. Forman, Joost P.H. Drenth, Stephen D. Ryder, Luigi Terracciano, Yuying Jin, Alexander Liberman, Richard Pencek, Uche Iloeje, Leigh MacConell, Pierre Bedossa. Clin Gastroenterol Hepatol. 2020 May;18(5):1170-1178.e6. doi: 10.1016/j.cgh.2019.09.050. Epub 2019 Oct 10. PMID: 31606455.

• Improved Quantitative Assessment of HBV-associated Liver Fibrosis Using Second Harmonic Generation Microscopy with Feature Selection

C.-Y.Hsiao, X.Teng, T.-H.Su. P.-H.Lee, J.-H.Kao, K.-W.Huang. Clin Res Hepatol Gastroenterol. 2020 Feb;44(1):12-20. doi: 10.1016/j.clinre.2019.04.003. Epub 2019 May 7.

• Comparing Hepatic Steatosis Distribution Patterns between Non-Alcoholic Fatty Liver Disease and Fatty Liver Disease with Chronic Hepatitis B by Second-Harmonic Generation/Two-Photon Excited Fluorescence Method
Zhenjie Zhuang, Huanjia Qu, Wenjun Yang, Juan Liu, Fuyan Wang, Yinlan Liu, Jianping Ding, Junping Shi. Ann Hepatol. May-Jun 2020;19(3):313-319. https://doi.org/10.1016/j.aohep.2019.11.003. Epub 2019 Dec 3.

• Concomitant Zonal Quantification of qSteatosis and qFibrosis in a Sub-study from EMMINENCE, a 12-month Phase 2b NASH study of MSDC-0602K

Stephen A. Harrison, Dean C.S. Tai, Yayun Ren, Elaine L.K. Chng, Howard C. Dittrich. NASH-Tag 2020 Poster Presentation.

FIBROSIS AND CANCER IN OTHER ORGANS

• The Significance of Fibrosis Quantification as a Marker in Assessing Pseudo-Capsule Status and Clear Cell Renal Cell Carcinoma Prognosis
Qin C, Yin H, Liu H, Liu F, Du Y, Xu T. Diagnostics (Basel). 2020;10(11):895. Published 2020 Nov 2. doi:10.3390/diagnostics10110895.

• Assessment of Progressive Alterations in Collagen Organization in the Postoperative Conjunctiva by Multiphoton Microscopy
Li-Fong Seet, Stephanie W. L. Chu, Xiao Teng, Li Zhen Toh, and Tina T. Wong. Biomed. Opt. Express 11, pp 6495-6515 (2020). https://doi.org/10.1364/BOE.403555.

• Multiphoton Microscopic Study of the Renal Cell Carcinoma Pseudocapsule: Implications for Tumour Enucleation
LYi Quan Tan, Wy Keat Tay, Li Yin Ooi, Thomas Paulraj Thamboo, Ho Yee Tiong. Urology. 2020 Oct;144:249-254. doi: 10.1016/j.urology.2020.06.064. Epub 2020 Jul 16.

• Prognostic Value of Desmoplastic Stroma in Intrahepatic Cholangiocarcinoma
Nathalie Guedj, Lorraine Blaise, François Cauchy, Miguel Albuquerque, Olivier Soubrane, Valérie Paradis. Mod Pathol. 2020 Aug 28. doi: 10.1038/s41379-020-00656-y. Online ahead of print.

• Quantitative Stain-free Imaging and Digital Profiling of Collagen Structure Reveal Diverse Survival of Triple Negative Breast Cancer Patients
Laurent Gole, Joe Yeong, Jeffrey Chun Tatt Lim, Kok Haur Ong, Hao Han, Aye Aye Thike, Yong Cheng Poh, Sidney Yee, Jabed Iqbal, Wanjin Hong, Bernett Lee, Weimiao Yu, Puay Hoon Tan. Breast Cancer Res 22, 42 (2020). https://doi.org/10.1186/s13058-020-01282-x.

2019

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FIBROSIS AND CANCER IN THE LIVER

• qFIBS for the Automated Quantitative Evaluation of Histological Evolution in Pediatric Nonalcoholic Steatohepatitis
Feng Liu, Jingmin Zhao, Leow Wei-Qiang, Ya-Yun Ren, Xiaoxiao Wang, Xiaohe Li, Huiying Rao, Wei Zhang, Aileen Wee, Lai Wei. Poster Presentation at The Liver Meeting (AASLD). 10 November 2019.

• Steatosis and Fibrosis Measured as Continuous Variables on Paired, Serial Liver Biopsies in the Resmetirom (MGL-3196) 36-week Phase 2 NASH Study
Stephen A Harrison, Dean Tai, Ya-Yun Ren, Rebecca A. Taub, Mustafa Bashir. Poster Presentation at The Liver Meeting (AASLD). 11 November 2019.

• Quantitative SHG Microscopy: Unraveling the Nano-architecture of the Cirrhotic Liver
Ian R. Wanless. Clin Res Hepatol Gastroenterol. 2019 Aug 12. pii: S2210-7401(19)30174-3. doi: 10.1016/j.clinre.2019.07.009.

• ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice
Weiguo Fan, Tianhui Liu, Wen Chen, Seddik Hammad, Thomas Longerich, Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling, Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley, Jinlin Hou, Jidong Jia, and Bing Sun. Gastroenterology. 2019 Nov;157(5):1352-1367.e13. doi: 10.1053/j.gastro.2019.07.036. Epub 2019 Jul 27.

• SHG/TPEF-based Image Technology Improves Liver Fibrosis Assessment of Minimally Sized Needle Biopsies
Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Yiwen Shi, Shanshan Wu, Hui Liu, Yayun Ren, Xiaojuan Ou, Jidong Jia, and Hong You. Hepatol Int 2019 Jul;13(4):501-509. doi: 10.1007/s12072-019-09955-2. Epub 2019 Jun 11.

• Digital Pathology: What is the Future?
V. Paradis, A. Quaglia. Journal of Hepatology. May 2019, Volume 70, Issue 5, Pages 1016–1018. https://doi.org/10.1016/j.jhep.2018.03.023.

• qBallooning: Automated Image Detection for Ballooning Degeneration in Non-alcoholic Steatohepatitis (NASH)
Wei-Qiang Leow, Wei Keat Wan, Josh Jie Hua Loh, Syed Muhammad Fahmy Alkaff, Dean C.S. Tai, Yayun Ren, George Boon-Bee Goh, Chee Kiat Tan, Pik Eu Chang, Kiat Hon Lim. 51. S89-S90. 10.1016/j.pathol.2018.12.236.

• MRI-PDFF Response in MGL-3196 and Placebo Treated Patients Predicts Reduction in Ballooning and Inflammation Components of NAS and NASH Resolution in a 36-week Serial Liver Biopsy Study
Stephen A. Harrison, Mustafa R. Bashir, Cynthia Guy, Rebecca Taub. Poster Presentation (SAT-347) at EASL 2019.

• The Glucocorticoid Antagonist ST001 Prevents Development of NASH and Improves Aspects of the Metabolic Syndrome in the DIAMOND™ Mouse Model
Rebecca Caffrey. Poster Presentation (PS-129) at EASL 2019.

• Long-Term Obeticholic Acid Treatment is Associated With Improvements in Collagen Morphometry in Patients With Primary Biliary Cholangitis
Andreas E. Kremer, Christopher L. Bowlus, Pierre Bedossa, Albert Parés, Lisa M. Forman, Joost P.H. Drenth, Stephen Ryder, Luigi Terracciano, Yuying Jin, Alexander Liberman, Richard Pencek, Leigh MacConell, Paul J. Pockros. Poster presentation (FRI-033) at EASL 2019.

• Morphometric Collagen Analysis Discerns Anti-fibrotic Effects of INT-767 and OCA in NASH Mouse Models Using Second Harmonic Generation Imaging
Li Chen, Mathieu Petitjean, Luciano Adorini, Jonathan Roth. Poster presentation (SAT-342) at EASL 2019.

• Quantification of Hepatic Steatosis in Chronic Liver Disease using Novel Automated Method of Second Harmonic Generation and Two-photon Excited Fluorescence
George Boon-Bee Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Tony Kiat Hon Lim, Chee Kiat Tan & Pik Eu Chang. Scientific Reports (2019) 9:2975, https://doi.org/10.1038/s41598-019-39783-1.
 
• A Quantitative Method (qVessel) Analysis: The Characteristics of Hepatic Vascular Changes in Different Causes
Zheng Xin Li, Zhao Zhi Min, Cheng Hai Liu, Ya Yun Ren, Xiao Teng, Dean Tai. Poster Presentation at APASL 2019.

• Comparison of Various Quantitative and Qualitative Collagen Analysis Methods in Early Liver Fibrosis
Reinout Stoop, Martine Morrison, Serene Lek, Arianne van Koppen, Lars Verschuren, Nicky van Trigt, Natascha van Lent, Roeland Hanemaaijer. Keystone Symposia 2019; Integrated Pathways of Disease in NASH and NAFLD.

FIBROSIS IN OTHER ORGANS, INCLUDING CANCER

• Quantitative Imaging and Characterization of Collagen Patterns in High Grade Serous Ovarian Carcinoma (HGSOC)
Ruby Huang. Poster Presentation on 28 Sep 19 at the ESMO Congress 2019.

• A Novel Nutritional Supplement Prevents Muscle Loss and Accelerates Muscle Mass Recovery in Caloric-restricted Mice
Anita M. van den Hoek, Gerben C.M. Zondag, Lars Verschuren, Christa de Ruiter, Joline Attema, Elly C. de Wit, Anne M.K. Schwerk, Bruno Guigas, Serene Lek, Annemarie Rietman, Rein Strijker, Robert Kleemann. https://doi.org/10.1016/j.metabol.2019.05.012. Metabolism - Clinical and Experimental, August 2019, Volume 97, Pages 57–67

• Multi-photon Microscopy for Characterization of Renal Cell Carcinoma Pseudocapsule: Implications for Tumour Enucleation
Quan Tan Yi, Tay Wy Keat, Ooi Yin Li, Teo Zui Chih Rachel, Tiong Ho Yee. 34th Annual EAU Congress.

2018

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FIBROSIS AND CANCER IN THE LIVER

• Application of Human NASH-based Transcriptome and Metabolome Profiles in Preclinical Models for the Translational Study of Drug Effects on Liver Fibrosis

Morrison MC, Verschuren L, Salic K, vanden Hoek AM, Menke A, Verheij J, Iruarrizaga-Lejarreta M, Turner S, Schwerk A, van Koppen A, Wielinga P Y, Mato JM, Hanemaaijer R, Alonso C, Kleemann R. Poster Presentation, HistoIndex Breakfast Meeting 2018.

• Collagen Structure Similarities between in vitro and in vivo Liver Fibrosis Models

Stroebel S, Rupp J, Kostadinova R, Gart E, Salic K, Morrison MC, Kleemann R, Lek S, Thoma E, Guye P. Poster Presentation, HistoIndex Breakfast Meeting 2018.

Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Yiwen Shi, Shanshan Wu, Xiaojuan Ou, Jidong Jia and Hong You. Poster Presentation, AASLD 2018.

• To Improve the Current Quantitative Assay of Liver Fibrosis By Second Harmonic Generation Microscopy
Kai-Wen Huang, Hepatitis Research Center, National Taiwan University Hospital. Poster Presentation, AASLD 2018.

Feng Liu, Boon Bee George Goh, Dina Tiniakos, Aileen Wee, Leow Wei-Qiang, Jingmin Zhao, Huiying Rao, Xiao-Xiao Wang, Qin Wang, Wei-Keat Wan, Kiat Hon Lim, Manuel Romero-Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee-Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Jason Chang and Lai Wei. Oral presentation, AASLD 2018.

David A Fraser, Xiaoyu Wang, Cristina Alonso, Serene Lek, Tore Skjaeret, Detlef Schuppan. Poster presentation, AASLD 2018.

Jolanta Jedrzkiewicz, Mary P Bronner, Mohamed E Salama, Jessica Kohan, Leslie R Rowe, Dean Tai, Elisabeth Malmberg and Erinn Downs-Kelly. Int J Pathol Clin Res 4:078. doi.org/10.23937/2469-5807/1510078.

Morrison MC, Verschuren L, Salic K, Verheij J, Menke A, Wielinga PY, Iruarrizaga-Lejarreta M, Gole L, Yu W, Turner S, Caspers MPM, Martínez-Arranz I, Pieterman EJ, Stoop R, van Koppen A,van den Hoek AM, Mato JM, Hanemaaijer R, Alonso C, Kleemann R. Hepatology Communications.

Chris Estes, Quentin M. Anstee, Maria Teresa Arias-Loste, ..., Lai Wei, Stefan Zeuzem, Homie Razavi. J Hepatol. 2018 Oct;69(4):896-904. doi: 10.1016/j.jhep.2018.05.036. Epub 2018 Jun 8.

Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan. PLoS ONE 13(6):e0199166. https://doi.org/10.1371/journal.pone.0199166.

Y. Wang, X. Liang, J. Yang, H. Wang, D. Tan, S. Chen, J. Cheng, Y. Chen, J. Sun, F. Rong, W. Yang, H. Liu, Z. Liu, Y. Zheng, J. Liang, S. Li, Z. Liu, J. Hou. Journal of Viral Hepatitis, https://doi.org/10.1111/jvh.12835.

Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Shanshan Wu, Hui Liu, Tailing Wang, Xiaojuan Ou, Jidong Jia, Hong You. Modern Pathology, https://doi.org/10.1038/s41379-018-0059-x.

Yameng Sun, Jialing Zhou, Xiaoning Wu, Yongpeng Chen, Hongxin Piao, Lungen Lu, Huiguo Ding, Yuemin Nan, Wei Jiang, Tailing Wang, Hui Liu, Xiaojuan Ou, Aileen Wee, Neil D. Theise, Jidong Jia, Hong You. Nature.com, Scientific Reports. 2018 Feb 14;8(1):2989. doi: 10.1038/s41598-018-21179-2.

Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. World Journal of Gastroenterology. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195.

 
FIBROSIS IN OTHER ORGANS, INCLUDING CANCER

S. Royce, C. Erdem, A. Tan, J. Jaffar, G. Westall, J. Bourke, C. Samuel, R. Widdop. Poster presentation at the European Respiratory Society Congress. 

Amlan Chakraborty, Jennifer C. Boer, Simon G. Royce, Cordelia Selomulya, Magdalena Plebanski. Poster presentation at the European Respiratory Society Congress. 

Carmine Ono, Serena Duchi, Cathal D O’Connell, Romane Blanchard, Andrea J O’Connor, Mark Scott, Gordon G Wallace, Peter FM Choong and Claudia Di Bella. Biofabrication, Volume 10, Number 4, October 2018. https://doi.org/10.1088/1758-5090/aad8d9

Joe Yeong, Laurent Cole, Jeffery Chun Tatt Lim, Aye Aye Thike, Jabed Iqbal, Bernett Lee, Weimiao Yu, Puay Hoon Tan. Poster presentation at the US Chinese American Pathologist (USCAP) Association Annual Meeting 2018.

2017

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FIBROSIS AND CANCER IN THE LIVER

Feng Liu, MD, Jing-Min Zhao, MD, Hui-Ying Rao, MD, Wei-Miao Yu, MD, Wei Zhang, MD, Neil D. Theise, MD, Aileen Wee, MBBS, FRCPath, FRCPA, and Lai Wei, MD. Am J Clin Pathol. 2017 Nov 20;148(6):502-512. doi: 10.1093/ajcp/aqx104

Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA

Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. Presented at AASLD 2017, October 20-23, 2017.

Martine Morrison, TNO, Metabolic Health Research, The Netherlands. Presented at AASLD 2017.

Feng Liu*, Jing-Min Zhao, Pei-Hao Liu, Hui-Ying Rao, Wei Zhang, Nan Wu, Lai Wei. Presented at EASL 2017.

Jason Chang , George Boon-Bee Goh, Wei Qiang Leow , Yayun Ren , Wei Keat Wan , Kiat Hon Lim , Chee Kiat Tan. Presented at EASL 2017.

M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Li Chen, Mohammad Naser, et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.

 
FIBROSIS AND CANCER IN OTHER ORGANS

Chrishan S. Samuel, and Timothy D. Hewitson. Front Pharmacol. 2017; 8: 824. Published online on 2017 Nov 14. doi: 10.3389/fphar.2017.00824.

Dr Yu Weimiao, presented at the 3rd Digital Pathology Congress Asia-Pacific 2017, Guangzhou, China.

Clinnovate Health UK, presented at the Glasgow Molecular Pathology Node Symposium 2017, University of Glasgow.

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R. Barton, H.Lee Sweeney presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

2016

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FIBROSIS AND CANCER IN THE LIVER

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Takeshi Imamura. Biochemistry and Biophysics Reports 8 (2016) 277–283; https://doi.org/10.1016/j.bbrep.2016.09.010.

Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP

Christopher J. Mulder, Zachary Goodman, Caroline Bolduc, Matthew F. Raines, Katherine M. Cebe, Lakshmi Alaparthi, Fanny Monge, Peter G. Traber, Dean Tai, Stephen A. Harrison. APASL 2016.

George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang Poster # 1518 at AASLD 2016

 
FIBROSIS AND CANCER IN OTHER ORGANS

L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France, Poster Presentation, AASLD Liver Meeting 2016

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. Poster #69 at The First International Conference on Tissue Repair, Regeneration , and Fibrosis, September 21-25, 2016.

Zannis Almpanis, Maria Demonakou, Dina Tiniakos. Ann Gastroenterol 2016; 29 (4): 445-453. DOI: http://dx.doi.org/10.20524/aog.2016.0046. 

2015

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FIBROSIS AND CANCER IN THE LIVER

Tong-Hong Wang, Tse-Ching Chen, Xiao Teng, Kung-Hao Liang & Chau-Ting Yeh. Scientific Reports, 5:12962; DOI: 10.1038/srep12962.

Liu, J., Lim, K. C., Li, H., Seck, H. L., Yu, X., Kok, S. W., et al. (2015). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9304, 93041K-.

David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015)

Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A

 
FIBROSIS AND CANCER IN OTHER ORGANS

Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804.

Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A. 

2014

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FIBROSIS AND CANCER IN OTHER ORGANS

Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65 

2011

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FIBROSIS AND CANCER IN OTHER ORGANS

Abraham T, Hirota JA, Wadsworth S, Knight DA. 2011;24(5):407-96

Conklin MW, Eickhoff JC, Riching KM, et al. The American journal of pathology. 2011;178(3):1221-32 

2009

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FIBROSIS AND CANCER IN THE LIVER

• Fibro-C-index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-Photon Microscopy

Tai DC, Tan N, Xu S, et al. Journal of biomedical optics. 2009; 14(4):044013

Sun W, Chang S, Tai DC, et al. Journal of biomedical optics. 2008;13(6):064010 

2008

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FIBROSIS AND CANCER IN OTHER ORGANS